Bacigalupi is a surname. Notable people with the surname include:
- Don Bacigalupi (born 1960), American curator and museum administrator
- Montserrat Sabater Bacigalupi (1940–2020), Spanish publisher
- Paolo Bacigalupi (born 1972), American science fiction and fantasy writer
- Rimo Bacigalupi (1901–1996), American botanist