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Clusane (known as Crüsane in the Brescian dialect) is a locality of the municipality of Iseo, in Lombardy, Italy. Until 1927, it was an independent municipality, with its last mayor being Francesco Martinelli.
Located on the Brescian shore of Lake Iseo, the small village might derive its name from "Clodius," which would give rise to "Clodianae." Clusane borders Paratico, Cremignane (a hamlet of Iseo), and Colombaro in the municipality of Corte Franca.