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David Callaway

This article is about the biological nanophysicist. For the American journalist, see David Callaway (journalist).
David J. E. Callaway
David J. E. Callaway
Alma materUniversity of Washington; Caltech
Scientific career
FieldsBiological physics
InstitutionsNew York University School of Medicine
ThesisQCD and Weak Asymmetries in Lepton Pair Production (1981)
Doctoral advisorErnest M. Henley

David James Edward Callaway is a biological nanophysicist in the New York University School of Medicine, where he is professor and laboratory director. He was trained as a theoretical physicist by Richard Feynman, Kip Thorne, and Cosmas Zachos, and was previously an associate professor at the Rockefeller University after positions at CERN and Los Alamos National Laboratory. Callaway's laboratory discovered potential therapeutics for Alzheimer's disease based upon apomorphine[1] after an earlier paper of his developed models of Alzheimer amyloid formation.[2] He has also initiated the study of protein domain dynamics[3] by neutron spin echo spectroscopy, providing a way to observe protein nanomachines in motion.[4][5]

Previous work includes the invention of the microcanonical ensemble approach to lattice gauge theory with Aneesur Rahman,[6][7] work on the convexity of the effective potential of quantum field theory,[8] work on Langevin dynamics in quantum field theory with John R. Klauder,[9] a monograph on quantum triviality,[10] constraints on the Higgs boson[11] and papers on black holes[12] and superconductors.[13] His work in these areas is highly cited and notable.[14][15]

  1. ^ Lashuel, H. A.; Hartley, D. M.; Balakhaneh, D.; Aggarwal A.; Teichberg S.; Callaway, D. J. E. (2002). "New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease". J Biol Chem. 277 (45): 42881–42890. doi:10.1074/jbc.M206593200. PMID 12167652.
  2. ^ Tjernberg, L. O.; Callaway, D. J. E.; Tjernberg, A.; Hahne, S.; Lilliehöök, C.; Terenius, L.; Thyberg, J.; Nordstedt, C. (1999). "A molecular model of Alzheimer amyloid ß-peptide fibril formation". J Biol Chem. 274 (18): 12619–12625. doi:10.1074/jbc.274.18.12619. PMID 10212241.
  3. ^ Bu Z, Callaway DJ (2011). "Proteins move! Protein dynamics and long-range allostery in cell signaling". In Donev R (ed.). Protein Structure and Diseases. Advances in Protein Chemistry and Structural Biology. Vol. 83. Academic Press. pp. 163–221. doi:10.1016/B978-0-12-381262-9.00005-7. ISBN 9780123812629. PMID 21570668.
  4. ^ Bu, Z.; Biehl, R; Monkenbusch, M.; Richter, D.; Callaway, D. J. E. (2005). "Coupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy". Proc Natl Acad Sci USA. 102 (49): 17646–17651. Bibcode:2005PNAS..10217646B. doi:10.1073/pnas.0503388102. PMC 1345721. PMID 16306270.
  5. ^ Callaway DJ, Nicholl ID, Shi B, Reyes G, Farago B, Bu Z (2024). "Nanoscale dynamics of the cadherin-catenin complex bound to vinculin revealed by neutron spin echo spectroscopy". Proceedings of the National Academy of Sciences of the United States of America. 129 (39). doi:10.1073/pnas.2408459121. PMC 11441495. PMID 39298480.
  6. ^ D. J. E. Callaway; A. Rahman (1982). "Microcanonical Ensemble Formulation of Lattice Gauge Theory". Phys. Rev. Lett. 49 (9): 613–616. Bibcode:1982PhRvL..49..613C. doi:10.1103/PhysRevLett.49.613.
  7. ^ D. J. E. Callaway; A. Rahman (1983). "Lattice gauge theory in the microcanonical ensemble" (PDF). Phys. Rev. D. 28 (6): 1506–1514. Bibcode:1983PhRvD..28.1506C. doi:10.1103/PhysRevD.28.1506.
  8. ^ D. J. E. Callaway; D. J. Maloof (1982). "Effective potential of lattice φ4 theory". Phys. Rev. D. D27 (2): 406–411. Bibcode:1983PhRvD..27..406C. doi:10.1103/PhysRevD.27.406.
  9. ^ D. J. E. Callaway; F. Cooper; J. R. Klauder; H. A. Rose (1985). "Langevin simulations in Minkowski space". Nuclear Physics B. 262 (1): 19–32. Bibcode:1985NuPhB.262...19C. doi:10.1016/0550-3213(85)90061-6. S2CID 122569576.
  10. ^ D. J. E. Callaway (1988). "Triviality Pursuit: Can Elementary Scalar Particles Exist?". Physics Reports. 167 (5): 241–320. Bibcode:1988PhR...167..241C. doi:10.1016/0370-1573(88)90008-7.
  11. ^ D. J. E. Callaway (1984). "Non-triviality of gauge theories with elementary scalars and upper bounds on Higgs masses" (PDF). Nuclear Physics B. 233 (2): 189–203. Bibcode:1984NuPhB.233..189C. doi:10.1016/0550-3213(84)90410-3.
  12. ^ Callaway, D. (1996). "Surface tension, hydrophobicity, and black holes: The entropic connection". Physical Review E. 53 (4): 3738–3744. arXiv:cond-mat/9601111. Bibcode:1996PhRvE..53.3738C. doi:10.1103/PhysRevE.53.3738. PMID 9964684. S2CID 7115890.
  13. ^ David J. E. Callaway (1990). "On the remarkable structure of the superconducting intermediate state". Nuclear Physics B. 344 (3): 627–645. Bibcode:1990NuPhB.344..627C. doi:10.1016/0550-3213(90)90672-Z.
  14. ^ "Inspire".
  15. ^ "David J. E. Callaway".
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