KATNA1

KATNA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RPA
Identifiers
Aliases	KATNA1, katanin catalytic subunit A1
External IDs	OMIM: 606696; MGI: 1344353; HomoloGene: 56014; GeneCards: KATNA1; OMA:KATNA1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,648,972 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,638,914 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; gonad; ; left testis; ; right testis; ; Achilles tendon; ; retinal pigment epithelium; ; testicle; ; gastrocnemius muscle; ; Descending thoracic aorta;
	Top expressed in
	granulocyte; ; epiblast; ; bone marrow; ; zygote; ; zone of skin; ; ileum; ; primary oocyte; ; thymus; ; secondary oocyte; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; microtubule binding; microtubule-severing ATPase activity; protein binding; protein heterodimerization activity; hydrolase activity; ATP binding; ATPase activity; isomerase activity;
Cellular component	cytoplasm; spindle pole; midbody; microtubule; cytoskeleton; nucleus; microtubule organizing center; spindle; mitotic spindle pole; centrosome;
Biological process	cell division; microtubule severing; cell cycle; cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	11104
	23924
	ENSG00000186625
	ENSMUSG00000019794
	O75449
	Q9WV86
	NM_001204076; NM_007044
	NM_011835
	NP_001191005; NP_008975
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.^[5]^[6]

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019794 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.
^ ^a ^b "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019794 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9658175-5] McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.

[entrez-6] "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

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KATNA1

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