The lake of fire is a religious after-death concept.
Lake of Fire may also refer to:
- Lake of Fire (album), a 2006 album by Shaye
- Lake of Fire (film), a 2006 documentary film about abortion
- ""Lake of Fire" (song), a song by the Meat Puppets and covered by Nirvana
- "Lake of Fire", a song by Nocturnus from their 1990 album The Key
- "Lake of Fire", a song by Boondox from his 2006 album The Harvest
- "The Lake of Fire", a song by Macabre from their 2020 album Carnival of Killers
- The 2012 Alberta general election, in which controversial comments made by a candidate about "gays burning in a lake of fire" majorly affected the election