Mardyke may refer to:
- Mardyke, a district of Cork, Ireland containing:
- Mardyke (UCC), a sports venue associated with University College Cork (UCC)
- Mardyke (cricket ground), home ground of Cork County Cricket Club
- Mardyke (river), a tributary of the River Thames.
- Mardyke Estate, a housing development in east London.