Mule Creek Junction is a former community in Niobrara County, Wyoming at the junction of US 18 and US 85.[citation needed]
| Direction | via | Destination | Distance from Mule Creek Junction |
|---|---|---|---|
| North | US 85 | Newcastle, Wyoming | 33 miles (53 km) |
| East | US 18 | Edgemont, South Dakota | 22 miles (35 km) |
| South | US 18/US 85 | Lusk, Wyoming | 46 miles (74 km) |