Nero Wolfe is a fictional detective character.
Nero Wolfe also may refer to:
- Nero Wolfe (film), a 1977 ABC TV movie starring Thayer David and Tom Mason
- Nero Wolfe (1981 TV series), an NBC TV series starring William Conrad and Lee Horsley
- Nero Wolfe (1982 radio series), a 1982 Canadian Broadcasting Corporation radio series starring Mavor Moore
- Nero Wolfe (2001 TV series), also known as A Nero Wolfe Mystery a 2001–2002 A&E television network series starring Maury Chaykin and Timothy Hutton