Ralphie is a masculine given name, often a diminutive form (hypocorism) of Ralph. It may refer to:
- Ralphie May (1972–2017), American stand-up comedian and actor
- Ralph "Ralphie" Cifaretto, a character on the TV series The Sopranos
- Ralphie Tennelli, a character on the TV series The Magic Schoolbus and The Magic School Bus Rides Again
- Ralphie the Buffalo, mascot of the University of Colorado Buffaloes